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乔云波

2021年07月26日 

基本情况:乔云波,博士,副教授,硕士生导师,广州市青年后备人才,获2019年广东省自然科学基金杰出青年项目、国家重点研发计划、国家自然科学基金等资助。

科研:结合新型高通量测序技术、基因编辑技术和表观调控研究方法,研究早期胚胎发育、细胞定向分化和疾病发生等过程中的表观遗传调控机制;开发和优化新型基因编辑工具,用于疾病模型构建和基因治疗新技术研发。先后主持国家自然科学基金、省部级基金和地方基金项目5项,以第一或者通讯作者(含共同)发表SCI论文十余篇,其中包括Cell Research (2019, 2018, 2012), Nature Communication (2021a, 2021b, 2020), Molecular Therapy (2020), Cell Reports (2019, 2017)等,申请国家发明专利4项(授权2项)。

联系方式:ybqiao84@163.com

 

代表性论文:

1. Ye, B.*, Fan, D.*, Xiong, W.*, Li, M., Yuan, J., Jiang, Q., Zhao, Y., Lin, J., Liu, J., Lv, Y., Wang, X., Li, Z.#, Su, J.#,Qiao, Y.# (2021) Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis. Nature Comm 12: 4457.

2. Li, J.*, Yu, W.*, Huang, S.*, Wu, S., Li, L., Zhou, J., Cao, Y., Huang X.#, Qiao, Y.# (2021) Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity. Nature Comm 12 (1): 2287.

3. Qiao, Y.*,#, Ren, C.*, Huang, S.*, Yuan, J.*, Liu, X.*, Fan, J., Lin, J., Wu, S., Chen, Q., Bo, X., Li, X., Huang, X., Liu, Z.#, Shu, W.# (2020) High-resolution annotation of the mouse preimplantation embryo transcriptome using long-read sequencing. Nature Comm 11: 2653.

4. Liu, Y.*, Li, J.*, Zhou, C.*, Meng, B.*, Wei, Y., Yang, G., Lu, Z., Shen, Q., Zhang, Y., Yang, H.#, Qiao, Y.#(2019) Allele-specific genome editing of imprinting genes by preferentially targeting non-methylated loci using Staphylococcus aureus Cas9 (SaCas9). Science Bulletin. 2019, 64 (21), 1592-1600

5. Yang, G.*, Zhou, C.*, Wang, R.*, Huang, S., Wei, Y., Yang, X., Liu, Y., Li, J., Lu, Z., Ying, W., Li, X., Jing, N., Huang, X.#, Yang, H.#, Qiao, Y.# (2019) Base editing-mediated R17H substitution in histone H3 reveals its methylation-dependent regulation of Yap signaling and early mouse embryo development. Cell Rep 26(2), 302-312.